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Trans-Synaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1
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| 4 MB | Adobe PDF |
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Throughout the brain, patterns of activity in postsynaptic neurons
influence the properties of synaptic inputs. Such feedback
regulation is central to neural network stability that underlies
proper information processing and feature representation in the
central nervous system. At the cellular level, tight coupling of
presynaptic and postsynaptic function is fundamental to neural
computation and synaptic plasticity. The cohort of protein
complexes at the pre and postsynaptic membrane allows for tight
synapse-specific segregation and integration of diverse
molecular and electrical signals.(...)