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Star-Shaped Gold Nanoparticles as Friendly Interfaces for Protein Electrochemistry: the Case Study of Cytochrome c

2019-09-02Artigo científico Acesso aberto
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dc.contributor.authorSilveira, Célia M.
dc.contributor.authorZumpano, Rosaceleste
dc.contributor.authorMoreira, Miguel
dc.contributor.authorde Almeida, Miguel Peixoto
dc.contributor.authorOliveira, Maria João
dc.contributor.authorBento, Marina
dc.contributor.authorMontez, Cláudia
dc.contributor.authorPaixão, Inês
dc.contributor.authorFranco, Ricardo
dc.contributor.authorPereira, Eulália
dc.contributor.authorAlmeida, M. Gabriela
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionUNINOVA-Instituto de Desenvolvimento de Novas Tecnologias
dc.contributor.pblWILEY-V C H VERLAG GMBH
dc.date.accessioned2020-06-29T22:15:20Z
dc.date.available2022-03-09T01:31:27Z
dc.date.embargoedUntil2020-09-12
dc.date.issued2019-09-02
dc.descriptionUID/QUI/50006/2019 POCI‐01‐0145‐FEDER‐007265 UID/Multi/04378/2019 POCI‐01‐0145‐FEDER‐007728 PTDC/NAN‐MAT/30589/2017 grant NORTE‐01‐0145‐FEDER‐000011 SFRH/BD/132057/2017
dc.description.abstractGold nanostars with an average tip-to-tip length of 52±6 nm were functionalized with different capping agents and used as electrode modification materials for protein electrochemistry. Direct electron transfer between cytochrome c and nanostar-coated pyrolytic graphite electrodes was observed with the protein in solution. The electrochemical response was improved at nanostars functionalized with a 1 : 1 mixture of 11-mercaptoundecanoic acid and 4-mercaptobenzoic acid in comparison with gold nanospheres coated with a similar functionalization. Further immobilization of cytochrome c on pyrolytic graphite while conjugated with the same nanostars guaranteed the maintenance of the protein's native properties, whereas direct adsorption on the bare or nanostar-modified electrodes resulted in an altered conformational state. The pseudo-peroxidase activity of the altered cytochrome c was enhanced in the presence of the nanostars.en
dc.description.versionpublished
dc.format.extent8
dc.format.extent856327
dc.identifier.doi10.1002/celc.201901393
dc.identifier.issn2196-0216
dc.identifier.otherPURE: 18059430
dc.identifier.otherPURE UUID: c8286ba8-765b-4e10-b853-73c05ec96a07
dc.identifier.otherScopus: 85073005171
dc.identifier.otherWOS: 000485947800044
dc.identifier.urihttp://hdl.handle.net/10362/100120
dc.identifier.urlhttps://www.scopus.com/pages/publications/85073005171
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F95983%2F2013/PT
dc.subjectcytochrome c
dc.subjectdirect electron transfer
dc.subjectgold nanostars
dc.subjectnanoparticles
dc.subjectprotein electrochemistry
dc.subjectCatalysis
dc.subjectElectrochemistry
dc.titleStar-Shaped Gold Nanoparticles as Friendly Interfaces for Protein Electrochemistry: the Case Study of Cytochrome cen
dc.typejournal article
degois.publication.firstPage4696
degois.publication.issue17
degois.publication.lastPage4703
degois.publication.titleChemelectrochem
degois.publication.volume6
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/95983/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F95983%2F2013/PT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationf0a2a89a-20b5-474f-8dc1-36c310c57dce
relation.isProjectOfPublication.latestForDiscoveryf0a2a89a-20b5-474f-8dc1-36c310c57dce

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