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Resumo(s)
The baker’s yeast Saccharomyces cerevisiae has been extensively explored for our understanding of fundamental cell biology processes highly conserved in the eukaryotic kingdom. In this context, they have proven invaluable in the study of complex mechanisms such as those involved in a variety of human disorders. Here, we first provide a brief historical perspective on the emergence of yeast as an experimental model and on how the field evolved to exploit the potential of the model for tackling the intricacies of various human diseases. In particular, we focus on existing yeast models of the molecular underpinnings of Parkinson’s disease (PD), focusing primarily on the central role of protein quality control systems. Finally, we compile and discuss the major discoveries derived from these studies, highlighting their far-reaching impact on the elucidation of PD-associated mechanisms as well as in the identification of candidate therapeutic targets and compounds with therapeutic potential.
Descrição
This work was supported by Fundação para a Ciência e Tecnologia project PTDC/BIA-BCM/117975/2010, fellowships SFRH/BPD/101646/2014 (ST) and
SFRH/BD/73429/2010 (DM), and IF/01097/2013 (CNS). This work was also supported by the BacHBerry project, co-funded by the European Commission in the 7th Framework Programme (Project No. FP7-613793). RM is supported
by a BacHBerry fellowship. TFO is supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB).
Palavras-chave
Parkinson’s disease synucleinopathies protein misfolding neurodegeneration alpha-synuclein SDG 3 - Good Health and Well-being