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A variante genética c825t da subunidade β3 da proteína G associa‐se com a hipertensão arterial numa população portuguesa

2018-06Artigo científico Acesso aberto
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dc.contributor.authorSousa, Ana Célia
dc.contributor.authorPalma dos Reis, Roberto
dc.contributor.authorPereira, Andreia
dc.contributor.authorBorges, Sofia
dc.contributor.authorGouveia, Sara
dc.contributor.authorSpínola, Adelaide
dc.contributor.authorFreitas, Ana Isabel
dc.contributor.authorGuerra, Graça
dc.contributor.authorGóis, Teresa
dc.contributor.authorRodrigues, Mariana
dc.contributor.authorHenriques, Eva
dc.contributor.authorOrnelas, Ilídio
dc.contributor.authorFreitas, Carolina
dc.contributor.authorPereira, Décio
dc.contributor.authorBrehm, António
dc.contributor.authorMendonça, Maria Isabel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSociedade Portuguesa de Cardiologia | Elsevier
dc.date.accessioned2023-01-18T22:10:10Z
dc.date.available2023-01-18T22:10:10Z
dc.date.issued2018-06
dc.descriptionFinanciamento: Programa Operacional de Valorização do Potencial Económico e Coesão Territorial da Região Autónoma da Madeira (Intervir+)
dc.description.abstractIntroduction: Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure. This genetic variant has been described as a risk factor for hypertension, although study results are controversial. Objective: The objective of this study was to analyze the association of the C825T polymorphism of the GNB3 gene with the occurrence of hypertension in a Portuguese population from the Madeira archipelago. Methods: A case‐control study was performed with 1641 Caucasian individuals (mean age 50.6±8.1 years), 848 with hypertension and 793 controls. Blood was collected from all participants for biochemical and genetic analysis, including genotyping of the C825T polymorphism. Logistic regression analysis was performed to determine which variables were significantly associated with the onset of hypertension. Statistical analyses were performed using IBM SPSS version 19.0 and p‐values <0.05 were considered statistically significant. Results: In our study, there was a significant association between the C825T polymorphism of the GNB3 gene and the occurrence of hypertension (odds ratio 1.275; 95% confidence interval 1.042‐1.559; p=0.018) in the dominant model, after multivariate analysis. Conclusion: We conclude that the C825T polymorphism of the beta 3 subunit of G protein is significantly and independently associated with the occurrence of hypertension in the study population.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent825518
dc.identifier.doi10.1016/j.repc.2017.09.018
dc.identifier.issn0870-2551
dc.identifier.otherPURE: 4310589
dc.identifier.otherPURE UUID: 5533468f-aec2-4e20-a930-98fa27a03606
dc.identifier.otherScopus: 85047448826
dc.identifier.otherPubMed: 29853161
dc.identifier.otherWOS: 000437849800009
dc.identifier.urihttp://hdl.handle.net/10362/147782
dc.identifier.urlhttps://www.scopus.com/pages/publications/85047448826
dc.language.isopor
dc.peerreviewedyes
dc.subjectCase‐control study
dc.subjectG protein
dc.subjectGNB3
dc.subjectHypertension
dc.subjectPolymorphisms
dc.subjectCardiology and Cardiovascular Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleA variante genética c825t da subunidade β3 da proteína G associa‐se com a hipertensão arterial numa população portuguesapt
dc.title.alternativeThe genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese populationen
dc.typejournal article
degois.publication.firstPage499
degois.publication.issue6
degois.publication.lastPage507
degois.publication.titleRevista Portuguesa de Cardiologia
degois.publication.volume37
dspace.entity.typePublication
rcaap.rightsopenAccess

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