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Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis

2023-04Artigo científico Acesso aberto
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dc.contributor.authorWeber, Juliana Inês
dc.contributor.authorRodrigues, Armanda Viana
dc.contributor.authorValério-Bolas, Ana
dc.contributor.authorNunes, Telmo
dc.contributor.authorCarvalheiro, Manuela
dc.contributor.authorAntunes, Wilson
dc.contributor.authorAlexandre-Pires, Graça
dc.contributor.authorda Fonseca, Isabel Pereira
dc.contributor.authorSantos-Gomes, Gabriela
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-07-17T22:15:27Z
dc.date.available2023-07-17T22:15:27Z
dc.date.issued2023-04
dc.descriptionFunding Information: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020 and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2023 by the authors.
dc.description.abstractLeishmaniasis is a parasitic disease caused by different species of Leishmania and transmitted through the bite of sand flies vector. Macrophages (MΦ), the target cells of Leishmania parasites, are phagocytes that play a crucial role in the innate immune microbial defense and are antigen-presenting cells driving the activation of the acquired immune response. Exploring parasite–host communication may be key in restraining parasite dissemination in the host. Extracellular vesicles (EVs) constitute a group of heterogenous cell-derived membranous structures, naturally produced by all cells and with immunomodulatory potential over target cells. This study examined the immunogenic potential of EVs shed by L. shawi and L. guyanensis in MΦ activation by analyzing the dynamics of major histocompatibility complex (MHC), innate immune receptors, and cytokine generation. L. shawi and L. guyanensis EVs were incorporated by MΦ and modulated innate immune receptors, indicating that EVs cargo can be recognized by MΦ sensors. Moreover, EVs induced MΦ to generate a mix of pro- and anti-inflammatory cytokines and favored the expression of MHCI molecules, suggesting that EVs antigens can be present to T cells, activating the acquired immune response of the host. Since nano-sized vesicles can be used as vehicles of immune mediators or immunomodulatory drugs, parasitic EVs can be exploited by bioengineering approaches for the development of efficient prophylactic or therapeutic tools for leishmaniasis.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent25
dc.format.extent10968547
dc.identifier.doi10.3390/cells12081101
dc.identifier.issn2073-4409
dc.identifier.otherPURE: 64196786
dc.identifier.otherPURE UUID: 3ffd316f-2b6b-4447-9692-f9991a08cdbc
dc.identifier.otherScopus: 85156199516
dc.identifier.otherPubMed: 37190011
dc.identifier.otherPubMedCentral: PMC10137031
dc.identifier.otherWOS: 000979353700001
dc.identifier.otherORCID: /0000-0001-9264-3887/work/151389906
dc.identifier.otherORCID: /0000-0003-4261-3879/work/163979125
dc.identifier.urihttp://hdl.handle.net/10362/155416
dc.identifier.urlhttps://www.scopus.com/pages/publications/85156199516
dc.language.isoeng
dc.peerreviewedyes
dc.subjectextracellular vesicles
dc.subjectimmunomodulation
dc.subjectLeishmania guyanensis
dc.subjectLeishmania shawi
dc.subjectleishmaniasis
dc.subjectmacrophages
dc.subjectQR180 Immunology
dc.subjectQR Microbiology
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectParasitology
dc.subjectImmunology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleInsights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensisen
dc.typejournal article
degois.publication.issue8
degois.publication.titleCells
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

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