Publication . Ferreira, Ana Rita Tomé; Pousada, Claudina Rodrigues-; Menezes, Regina
Human exposure to elevated levels of inorganic arsenic (As) poses the
greatest threat to global public health. However, arsenic trioxide (ATO) is
presently the most active antineoplastic agent in the treatment of acute
promyelocytic leukaemia (APL) (Trisenox®, Teva Pharm). Despite the
success of this drug, the actual mechanism of action is complex and is not
completely understood. We have therefore investigated the mechanisms by
which the cell responds to arsenic that perturb homeostasis, and how
homeostasis can subsequently be restored, while also focusing on the
mechanistic understanding of individual protein regulation important for the
cell to thwart the cytotoxic effects of arsenic.(...)
