ITQB: DSB-PhD Theses
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- Structure and Dynamics of Pathogenic Scaffold ProteinsPublication . Hernandez, Guillem"Pathogens have evolved sophisticated mechanisms to control the host by hijacking and redirecting cellular processes. In this context, pathogens encode intrinsically disordered (ID) proteins (IDP) and/or proteins containing ID regions (IDR) that, once insid e host cells, employ their inherent flexibility/plasticity to mimic host protein interaction patterns to redirect the host immune responses and metabolism to induce beneficial conditions for the pathogen.(...)"
- Unraveling structural dynamics of Tir-Host interactions blocking immune responsePublication . Vieira, Marta"Innate immunity is the first line of defense against pathogenic microorganisms. However, pathogens have evolved sophisticated mechanisms to evade immune responses during infection, often by delivering effectors/virulence factors into host cells. (...)"