Pousada, Claudina Rodrigues-Menezes, ReginaFerreira, Ana Rita Tomé2017-04-192017-04-192015-12-212015-12http://hdl.handle.net/10362/20508Human exposure to elevated levels of inorganic arsenic (As) poses the greatest threat to global public health. However, arsenic trioxide (ATO) is presently the most active antineoplastic agent in the treatment of acute promyelocytic leukaemia (APL) (Trisenox®, Teva Pharm). Despite the success of this drug, the actual mechanism of action is complex and is not completely understood. We have therefore investigated the mechanisms by which the cell responds to arsenic that perturb homeostasis, and how homeostasis can subsequently be restored, while also focusing on the mechanistic understanding of individual protein regulation important for the cell to thwart the cytotoxic effects of arsenic.(...)engdoctoral thesis