Costa, JúliaGomes, Catarina Heitor2015-01-162015-01-162010-012015-01http://hdl.handle.net/10362/14114"Amyotrophic Lateral Sclerosis (ALS) is the most severe and common adult onset disorder that affects motor neurons in the spinal cord, brainstem and cortex, resulting in progressive weakness and death from respiratory failure within two to five years of symptoms onset(...)engdoctoral thesis