Lin, Chia LinHuang, Pei-ChiGräßle, SimoneGrathwol, ChristophTremouilhac, PierreVanderheiden, SylviaHodapp, PatrickHerres-Pawlis, SonjaHoffmann, AlexanderFink, FabianManolikakes, GeorgOpatz, TillLink, AndreasMarques, M. Manuel B.Daumann, Lena J.Tsotsalas, ManuelBiedermann, FrankMutlu, HaticeTäuscher, EricBach, FelixDrees, TimNeumann, SteffenHarivyasi, Shashank S.Jung, NicoleBräse, Stefan2025-06-032025-06-032025-01-222052-4463PURE: 117430517PURE UUID: ce4670c1-784a-4790-a921-3569826d7b33Scopus: 85216608271PubMed: 39843501WOS: 001402627100005PubMedCentral: PMC11754846ORCID: /0000-0002-6712-752X/work/185323898http://hdl.handle.net/10362/183804Funding Information: The results of this project could be gained due to the support of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) for the projects Chemotion ELN (project number: 266379491), DFG core facilities Compound Platform (project number: 284178167) and the NFDI4Chem (project number: 441958208). The project group was further supported by the project ELN ElCh of the BMBF cluster ETOS (03ZU1205OA). Publisher Copyright: © The Author(s) 2025.Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in research data repositories in a FAIR manner. Nevertheless, in order to make chemistry a sustainable discipline, obtaining FAIR data is insufficient and a comprehensive concept that includes preservation of materials is needed. In order to offer a comprehensive infrastructure to find and access data and materials that were generated in chemistry projects, we combined the infrastructure Chemotion repository with an archive for chemical compounds. Samples play a key role in this concept: we describe how FAIR metadata of a virtual sample representation can be used to refer to a physically available sample in a materials’ archive and to link it with the FAIR research data gained using the said sample. We further describe the measures to make the physically available samples not only FAIR through their metadata but also findable, accessible and reusable.123054377engStatistics and ProbabilityInformation SystemsEducationComputer Science ApplicationsStatistics, Probability and UncertaintyLibrary and Information Sciencesjournal article10.1038/s41597-025-04404-2https://www.scopus.com/pages/publications/85216608271https://www.webofscience.com/wos/woscc/full-record/WOS:001402627100005