Cortes, SofiaAlbuquerque, AndreiaCabral, Lília I LLopes, LilianaCampino, LeneaCristiano, Maria L S2018-05-142018-05-142015-08-010066-4804PURE: 1645540PURE UUID: 03f47d54-c817-4fb8-96c5-97b10072d421Scopus: 84940196134WOS: 000362952000090PubMed: 26014947ORCID: /0000-0001-5850-6950/work/69040056http://www.scopus.com/inward/record.url?scp=84940196134&partnerID=8YFLogxKPMID: 26014947 WOS:000362952000090Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.4250059engPharmacologyInfectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingjournal article10.1128/AAC.00298-15https://www.scopus.com/pages/publications/84940196134