Moita, Luís FerreiraColaço, Henrique Guerra Gonçalves2020-05-202021-02-012020-01-172020-01http://hdl.handle.net/10362/97992"Optimal organismal function and survival in adverse conditions require robust homeostatic responses to challenging environmental conditions. Surviving a severe infection requires the synergy between resistance and disease tolerance, two evolutionarily conserved defense strategies that limit disease severity. Sepsis – a dysregulated host response to infection that leads to high risk of death – is a prime example of extreme homeostasis disruption and therefore constitutes an excellent model to study homeostasis and inter-organ communication principles.(...)"enginfectionhomeostasissepsisantibioticsdoctoral thesis