Andrade, Lucas AlmeidaPaz, Wandklebson Silva daMelo, Luís Ricardo Santos deTavares, Débora dos SantosSousa, Alvaro Francisco Lopes deCamargo, Emerson Lucas SilvaVentura, Carla Aparecida ArenaSouza, Regina Claudia SilvaAraújo, Karina Conceição Gomes Machado deSouza, Carlos Dornels Freire deSantos, Allan Dantas dosCampos, Fagner Alfredo Ardisson CirinoSantos, Márcio Bezerra2025-10-202025-10-202025-09-152369-2960PURE: 132594526PURE UUID: f905846f-7468-489d-aea4-cad82f256d74Scopus: 105016422951PubMed: 40960187PubMedCentral: PMC12441753WOS: 001572735300001http://hdl.handle.net/10362/189544Publisher Copyright: © Lucas Almeida Andrade, Wandklebson Silva da Paz, Luís Ricardo Santos de Melo, Débora dos Santos Tavares, Alvaro Francisco Lopes de Sousa, Emerson Lucas Silva Camargo, Carla Aparecida Arena Ventura, Regina Claudia Silva Souza, Karina Conceição Gomes Machado de Araújo, Carlos Dornels Freire de Souza, Allan Dantas dos Santos, Fagner Alfredo Ardisson Cirino Campos, Márcio Bezerra Santos. OriginallBackground: Mortality from external causes is a major public health issue globally, with significant impacts on both lives and economies. In Brazil, external cause mortality has shown spatiotemporal variations across regions, influenced by social, economic, and demographic factors. Objective: This study aimed to examine the spatiotemporal dynamics of mortality from external causes in Brazil for 23 years (2000-2022), identifying patterns across regions and demographic groups and assessing the major contributing causes of death. Methods: This ecological study used data from the Brazilian Mortality Information System (SIM) and used joinpoint regression to analyze temporal trends, Moran I for spatial analysis, and Poisson scanning statistics for spatiotemporal patterns. A total of 3,240,023 deaths were analyzed, with specific attention given to regional and demographic disparities. Results: The study found that mortality from external causes remained significant, with men and young adults (20-39 years) having the highest rates of death. The main causes of death were assaults (36.61%), transport accidents (26.55%), falls (7.83%), and self-harm (7.43%). Despite an overall decrease in mortality, increases were observed in the North and Northeast regions and among the older adults. High-risk areas were predominantly located in the North, Northeast, and Central-West regions. The mortality trends varied by region, with significant differences in risk across the country. Conclusions: Although there was a general reduction in mortality from external causes in Brazil, this trend was not uniform across all regions. The North, Northeast, and Central-West regions showed the highest mortality risks, with men and young adults being the most affected demographic groups. These findings emphasize the need for targeted public health interventions that address the regional and demographic disparities in mortality from external causes.889200engaccidentsassaultsBraziliandeathsexternal causeshistorical seriesjoinpoint regressionMoran's Imortalitymortality information systemPoisson scanning statisticspopulation-based studypublic healthself harmSIMspatial analysisspatiotemporal analysistemporal trendsviolenceyoung adultsHealth InformaticsPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingSDG 16 - Peace, Justice and Strong Institutionsjournal article10.2196/68002https://www.scopus.com/pages/publications/105016422951