Sá-Leão, RaquelMuñoz-Almagro, CarmenFélix, Sofia2021-01-122027-07-312020-12-18http://hdl.handle.net/10362/110094"Streptococcus pneumoniae, or the pneumococcus, frequently colonizes the human nasopharynx, particularly in children. From the nasopharynx, the pneumococcus can transit to other body sites and cause disease such as otitis media, pneumonia, bacteremia and meningitis. Multivalent pneumococcal conjugate vaccines (PCV), targeting pneumococcal capsular types, or serotypes, have been designed and implemented since 2001, to reduce the incidence of pneumococcal disease worldwide. (...)"engpneumococcusnasopharynxdoctoral thesis101654170