Matos, RuteBrito, JoséCosta, Vanessa G2025-08-222025-08-222021-02-182021-01-21http://hdl.handle.net/10362/186748"Mycobacterium tuberculosis, the causative agent of tuberculosis, remains the leading cause of mortality from a single infectious organism, infecting nearly one-third of the global population. Emergence of multidrug and extremely drug resistant strains of M. tuberculosis represents a serious health problem and emphasizes the need to improve prevention and control of the disease. Regulation of gene expression through RNA metabolism is a key mechanism for bacterial growth, division and rapid accommodation to environmental conditions. Ribonucleases ensure maturation, degradation and quality control of RNA in all domains of life. (...)"engRNA degradationExoribonucleasesActivity assaysThermal stabilityRNB-familyMycobacterium tuberculosis;master thesis203230710