Zalewska, KarolinaPinto, IsabelCabrita, LuísZakrzewska, Malgorzata E.Noronha, João P.Nunes da Ponte, M.Branco, Luís C.2023-05-022023-05-022023-01-252073-4344PURE: 51576614PURE UUID: 6caabbb5-ed1f-41eb-a94e-8c2d89fdb63fScopus: 85148853014WOS: 000938971900001ORCID: /0000-0003-4499-4521/work/151368289ORCID: /0000-0003-1775-4274/work/151417779http://hdl.handle.net/10362/152340co-financed by the ERDF under the PT2020 Partnership agreement (POCI-01-0145-FEDER–007265) The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by the Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).Different Chiral Ionic Liquids (CIL) based on L-proline have been developed. Simple and efficient synthetic methodologies are used, allowing preparation in good yields for twelve novel CILs using L-proline as a cation or anion combined with suitable counter-ions. A detailed physical and chemical characterization of the CILs was performed to evaluate the influence of counter-ions on the final properties. The most promissory CILs were tested as efficient chiral catalysts in IL media for asymmetric Michael addition reactions of ketones and aldehydes to nitro-olefins. Similar or even better conversions and enantioselectivities (ee up to 95%) compared to the original L-proline were achieved. Additionally, a good product extraction performance using supercritical CO2 processes was obtained.161786414engasymmetric Michael reactionchiral ionic liquidsL-prolinesupercritical CO extractionCatalysisGeneral Environmental SciencePhysical and Theoretical Chemistryjournal article10.3390/catal13020270https://www.scopus.com/pages/publications/85148853014