Janody, FlorenceTavares, Sandra Raquel de Oliveira2019-01-072019-10-3120162016-11http://hdl.handle.net/10362/56699Tumorigenesis is a multistep process, by which cells acquire genetic and epigenetic alterations in oncogenes and tumour suppressor genes, which provide growth and/or survival advantage. Subsequent alterations may condemn these pre-malignant cells into malignant ones with invasive and metastatic abilities. Proto-oncogenes of the Src-family kinases have been linked to tumorigenesis and their over-expression and activation described in breast cancer. Increased Src activity has been associated with increased cell proliferation, survival, epithelialmesenchymal transition (EMT), migration, invasion and metastasis. Although Src is well-known to trigger cancer cell mobility, migration and invasion, through regulation of filamentous actin (F-actin), whether it also uses F-actin to promote proliferation and survival of tumour cells at pre-malignant stages remains unknown. Our lab has demonstrated that Src promotes apical F-actin accumulation in Drosophila epithelia. In turn, F-actin limits Src-induced apoptosis or tissue overgrowth.(...)engcytoskeletonbreast tumourdoctoral thesis