Castro, DiogoVasconcelos, Francisca Ferreira de2017-04-132017-07-012015-09-282015-07http://hdl.handle.net/10362/20489Neurogenesis is a cell differentiation program in which neural stem cells undergo extensive and precise changes in gene expression on their way to become neurons. These changes are controlled to large extent by the activity of lineage-specific transcription factors. Of particular importance are classical proneural factors, such as Ascl1 (a.k.a. Mash1), that function as master regulators of the neurogenic program and are both required and sufficient to induce a complete program of neuronal differentiation.(...)engdoctoral thesis