Carrera, Gonçalo V. S. M.Santos, Miguel M.Costa, AlexandraRebelo, Luis Paulo N.Marrucho, Isabel M.Nunes da Ponte, M.Branco, Luis C.2020-06-252020-06-252017-08-071144-0546PURE: 3838175PURE UUID: 741bcee3-7469-4c00-8a79-a60405fc6c01Scopus: 85026320974WOS: 000406192800007ORCID: /0000-0003-4499-4521/work/51947945ORCID: /0000-0001-8973-1595/work/75127764ORCID: /0000-0002-5247-2443/work/105033663http://hdl.handle.net/10362/99957Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.51265477engPROTIC IONIC LIQUIDSACTIVE PHARMACEUTICAL INGREDIENTSAMPICILLINFORMSCIPROFLOXACINACIDNORFLOXACINSTABILITYLIPOSOMESCatalysisGeneral ChemistryMaterials Chemistryjournal article10.1039/c7nj01398ahttps://www.scopus.com/pages/publications/85026320974