Palion-Gazda, JoannaLuz, AndréRaposo, Luis R.Choroba, KatarzynaNycz, Jacek E.Bieńko, AlinaLewińska, AgnieszkaErfurt, KarolBaptista, Pedro V.Machura, BarbaraFernandes, Alexandra R.Shul’pina, Lidia S.Ikonnikov, Nikolay S.Shul’pin, Georgiy B.2022-03-302022-03-302021-10-211420-3049PURE: 42510251PURE UUID: 0f55496e-c434-4e7f-9331-b233fd5de6b4Scopus: 85117575015PubMed: 34770772PubMedCentral: PMC8588223WOS: 000718483800001ORCID: /0000-0001-5255-7095/work/110591379ORCID: /0000-0003-2054-4438/work/110592139http://hdl.handle.net/10362/135536Nos. 19-03-00142 RFMEFI61917X0007 State Task 0082-2014-0007 (CITIS): AAAA-A17-117040610283-3 LA/P/0140/2020Methyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2 ] (1), [VO(2,5-(Me)2-quin)2 ] (2) and [VO(2-Me-quin)2 ] (3). Complexes 1–3 demonstrated high catalytic activity in the oxidation of hydrocarbons with H2 O2 in acetonitrile at 50◦ C, in the presence of 2-pyrazinecarboxylic acid (PCA) as a cocatalyst. The maximum yield of cyclohexane oxidation products attained was 48%, which is high in the case of the oxidation of saturated hydrocarbons. The reaction leads to the formation of a mixture of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. When triphenylphosphine is added, cyclohexyl hydroperoxide is completely converted to cyclohexanol. Consideration of the regioand bond-selectivity in the oxidation of n-heptane and methylcyclohexane, respectively, indicates that the oxidation proceeds with the participation of free hydroxyl radicals. The complexes show moderate activity in the oxidation of alcohols. Complexes 1 and 2 reduce the viability of colorectal (HCT116) and ovarian (A2780) carcinoma cell lines and of normal dermal fibroblasts without showing a specific selectivity for cancer cell lines. Complex 3 on the other hand, shows a higher cytotoxicity in a colorectal carcinoma cell line (HCT116), a lower cytotoxicity towards normal dermal fibroblasts and no effect in an ovarian carcinoma cell line (order of magnitude HCT116 > fibroblasts > A2780).233467590eng8-hydroxyquinolineBiological activityCatalytic propertiesCytotoxicity studiesVanadium(IV) complexesAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySDG 3 - Good Health and Well-beingjournal article10.3390/molecules26216364https://www.scopus.com/pages/publications/85117575015