Marques, MariaDelgado-Gomes, VascoJanuário, FábioLopes, CarlosJardim-Goncalves, RicardoAgostinho, Carlos2026-02-022026-02-022025-11-211424-8220PURE: 151759095PURE UUID: e2ab150b-e5db-41b5-9f8b-d7f15f3ccfaaScopus: 105024637073PubMed: 41374490WOS: 001635324600001PubMedCentral: PMC12693854http://hdl.handle.net/10362/199937Publisher Copyright: © 2025 by the authors.In recent years, healthcare is evolving to meet the needs of a growing and ageing population. To support better and more reliable care, a comprehensive and up-to-date Personal Health Record (PHR) is essential. Ideally, the PHR should contain all health-related information about an individual and be available for sharing with healthcare institutions. However, due to interoperability issues of the medical and fitness devices, most of the times, the PHR only contains the same information as the patient Electronic Health Record (EHR). This results in lack of health-related information (e.g., physical activity, working patterns) essential to address medical conditions, support prescriptions, and treatment follow-up. This paper introduces the B-Health IoT Box, a fog IoT computing framework for eHealth interoperability and data collection that enables seamless, secure integration of health and contextual data into interoperable health records. The system was deployed in real-world settings involving over 4500 users, successfully collecting and transmitting more than 1.5 million datasets. The validation shown that data was collected, harmonized, and properly stored in different eHealth platforms, enriching data from personal EHR with mobile and wearable sensors data. The solution supports real-time and near real-time data collection, fast prototyping, and secure cloud integration, offering a modular, standards-compliant gateway for digital health ecosystems. The health and health-related data is available in FHIR format enabling interoperable eHealth ecosystems, and better equality of access to health and care services.342234695engDigital healthEHRFHIRFog computingHISInteroperabilityIoTWearablesWorkplaceAnalytical ChemistryInformation SystemsAtomic and Molecular Physics, and OpticsBiochemistryInstrumentationElectrical and Electronic Engineeringjournal article10.3390/s25237116https://www.scopus.com/pages/publications/105024637073https://www.webofscience.com/wos/woscc/full-record/WOS:001635324600001