Ricardo, AnaCosta, EuniceMoura, Cláudia Consuelo Vieira Reis Leite2017-05-252016-092017-05http://hdl.handle.net/10362/20779The pharmaceutical interest to deliver drugs to the lungs has been increasing to treat local diseases like asthma or for systemic treatment, as insulin for diabetics. Pulmonary drug delivery enables a rapid drug action and bioavailability while avoiding the first pass metabolism and reducing the drug load required, minimizing adverse side effects and creating a more efficient therapy. The main goal of this work was to investigate, benchmark and optimize the different formulations and process parameters of the particle engineering technologies in order to optimize pulmonary drug delivery in dry powder inhalers.(...)engDry powder inhalersCarrier-based formulationCarrier-free formulationMulticomponent particlesParticle engineeringJet-millingdoctoral thesis101548362