Fonseca, Daniela P.Amorim, Ana C.Carreiro, Elisabete P.Ramalho, João P. PratesHermann, Gesine J.Federsel, Hans JürgenDuarte, Ana Rita C.Burke, Anthony J.2023-09-222023-09-2220232509-9396PURE: 72177522PURE UUID: 29cd69b6-4912-46d0-bd18-7de1bb845effScopus: 85165607183WOS: 001050277400001ORCID: /0000-0003-0800-0112/work/151371931http://hdl.handle.net/10362/158161© 2023 Wolters Kluwer Medknow Publications. All rights reserved.The organocatalyst cinchonidine-squaramide was immobilized within three different deep eutectic solvents (DESs): betaine:D-sorbitol: water, betaine: D-xylitol:water, and betaine:D-mannitol:water and evaluated in a well-known asymmetric Michael addition. These reactions provided excellent yields (up to 99%) and enantioselectivities (upto 98%) using only 1 mol% of organocatalyst. It was also possible to achieve 9 cycles in reactions with DES (betaine:D-sorbitol:water), proving the high recyclability of this system. In the reactions realized with only 0.5 mol% of organocatalyst, it was possible to achieve 5 cycles, and the products were obtained with high yields (up to 95%) and excellent enantioselectivities (up to 94%), using DES (betaine:D-sorbitol:water).71764967engbetainecinchonidine-squaramidedeep eutectic solvent (DES)immobilizationorganocatalysisCatalysisBiomaterialsMaterials Science (miscellaneous)Organic Chemistryjournal article10.1055/a-2117-9971https://www.scopus.com/pages/publications/85165607183