Aleixo, AnaNeuparth, NunoGonçalves, Nuno de AraújoAlmeida, Manuel de Sousa2019-05-302019-05-302019-05-282018-12-10http://hdl.handle.net/10362/71219Summary Hypertension is a leading cause of death in developed countries, and although there have been large investments in drugs aiming its control, there is still a staggering contrast between its high prevalence and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly involved. Sympathetic renal denervation has recently emerged as a device-based treatment for resistant hypertension. In this review, the pathophysiological mechanisms linking the sympathetic nervous system and cardiovascular disease are reviewed, focusing on resistant hypertension and the role of sympathetic renal denervation. An update on experimental and clinical results is provided, along with potential future indications for this device-based technique in other cardiovascular diseases.engSympathetic Renal DenervationBlood pressureSurrogate markersdoctoral thesis101489528