Sousa, HenriqueBranco, Patríciade Sousa Almeida, Manuelde Araújo Gonçalves, PedroGaspar, AugustaDores, HélderMesquita, João RodrigoAndrade, Maria JoãoNeuparth, NunoAleixo, AnaMendes, MiguelBarata, José Diogo2023-01-272023-01-272017-050870-2551PURE: 2763223PURE UUID: 3a156269-6fee-46fb-b154-6918098dd82bScopus: 85018706617PubMed: 28456548WOS: 000402001100003ORCID: /0000-0001-5149-7473/work/196571873http://hdl.handle.net/10362/148248Introduction: Sympathetic renal denervation (RDN) was developed as a treatment for the management of patients with resistant hypertension. This procedure may have a positive impact on hypertension-related target organ damage, particularly renal disease, but the evidence is still limited. Objective: To assess the impact of RDN on the albumin-to-creatinine ratio (ACR) at 12-month follow-up. Methods and Results: From a single-center prospective registry including 65 patients with resistant hypertension undergoing renal denervation, 31 patients with complete baseline and 12-month follow-up blood pressure (BP) measurements (both office and 24-h ambulatory blood pressure monitoring [ABPM]) and ACR were included in the present study. Mean age was 65±7 years, 52% were female, most (90%) had been diagnosed with hypertension for more than 10 years, 71% had type 2 diabetes and 33% had vascular disease in at least one territory. Mean estimated glomerular filtration rate was 73.6±25.1 ml/min/1.73 m2 and 15 patients (48%) had an ACR >30 mg/g. After 12 months, 22 patients were considered BP responders (73%). ACR decreased significantly from a median of 25.8 mg/g (interquartile range [IQR] 9.0-574.0 mg/g) to 14.8 mg/g (IQR 4.5-61.0 mg/g, p=0.007). When the results were split according to systolic BP responder status on ABPM, we found a significant reduction in responders (from 25.6 mg/g [IQR 8.7-382.8 mg/g] to 15.9 mg/g [IQR 4.4-55.0 mg/g], p=0.009), and a numerical decrease in the non-responder subgroup (from 165.0 mg/g [IQR 8.8-1423.5 mg/g] to 13.6 mg/dl [IQR 5.7-1417.0 mg/g], p=0.345). Conclusions: Besides significant reductions in blood pressure (both office and 24-h ABPM), renal denervation was associated with a significant reduction in ACR, a recognized marker of target organ damage.8728151engAlbuminuriaBlood pressureRenal denervationResistant hypertensionCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingjournal article10.1016/j.repc.2016.09.019https://www.scopus.com/pages/publications/85018706617