Andrade, JoséArraiano, CecíliaSeixas, André Filipe Coimbra e2026-03-032026-03-032026-01-082025-06-30http://hdl.handle.net/10362/200897"The RNA chaperone Hfq is a well-established post-transcriptional regulator in Gram-negative bacteria, where it facilitates small RNA–mRNA interactions. However, its role in Gram-positive bacteria remains poorly understood. In this thesis, we uncover novel functions for Hfq in the human pathogen Listeria monocytogenes, the causative agent of listeriosis, a severe foodborne disease. L. monocytogenes is a facultative intracellular bacterium that must withstand oxidative stress during infection, particularly the reactive oxygen species (ROS) generated by host immune cells.(...)"engRNA chaperone HfqGram-positive bacteriaoxidative stress responseiron homeostasisListeria monocytogenesdoctoral thesis101849753