Scholze, Alessandro RolimAlves, Josilene DáliaBerra, Thaís ZamboniRamos, Antônio Carlos VieiraPieri, Flávia MeneguettiPillon, Sandra CristinaMartins, Júlia TrevisanGaldino, Maria José QuinaMelo, Emiliana CristinaDelpino, Felipe MendesTártaro, Ariela FehrFronteira, InêsArcêncio, Ricardo Alexandre2022-09-152022-09-152022-07-011661-7827PURE: 46496803PURE UUID: ffb7b884-9b0c-43b0-b94b-f6a6dbe74493Scopus: 85132438208PubMed: 35805377ORCID: /0000-0003-1406-4585/work/118886593http://hdl.handle.net/10362/143762Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.(1) Background: Tuberculosis presents an epidemiological trend toward inequality, especially among people in social exclusion and situations of vulnerability. This study aimed to analyze territories with a concentration of people diagnosed with tuberculosis in a street situation and who partake in chronic use of alcohol, tobacco, and illicit drugs. We also analyzed trends in this health condition in southern Brazil. (2) Methods: Ecological study, developed in the 399 municipalities of Paraná, southern Brazil, with all tuberculosis cases in the homeless population registered in the Information System of Notifiable Diseases between 2014 and 2018. For data analysis, we used descriptive statistics, the Prais–Winsten autoregression method for the time series, and the Getis-Ord Gi technique* for spatial analysis. (3) Results: in total, 560 cases were reported. We found a predominance of alcohol, smoking, and illicit drug users, with an increasing trend in the state and clusters of spatial risk in the East health macro-region. (4) Conclusions: We observed territories with critical levels of highly vulnerable people who use psychoactive substances and are in a street situation. The results highlight the importance of incorporating public policies of social protection for these individuals and resolutive health services that receive these cases and assist in eradicating TB.1229458enghomeless personssubstance-related disorderstuberculosisvulnerable populationsPollutionPublic Health, Environmental and Occupational HealthHealth, Toxicology and MutagenesisSDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesSDG 17 - Partnerships for the GoalsSDG 1 - No Povertyjournal article10.3390/ijerph19137721https://www.scopus.com/pages/publications/85132438208