Ribau, A. M.Ferrás, L. L.Morgado, M. L.Rebelo, M.Pinho, F. T.Afonso, A. M.2025-02-142025-02-142024-08-170022-0833PURE: 110460653PURE UUID: 534b995f-a2ee-49e5-af41-59ae8632841dScopus: 85201383470ORCID: /0000-0003-4115-3516/work/178129595http://hdl.handle.net/10362/179086Funding Information: Open access funding provided by FCT|FCCN (b-on). Ângela M. Ribau would like to thank FCT - Fundação para a Ciência e a Tecnologia, for financial support through scholarship SFRH/BD/143950/2019. Ângela M. Ribau, Alexandre M. Afonso and Fernando T. Pinho also acknowledge FCT for financial support through LA/P/0045/2020 (ALiCE), UIDB/00532/2020 and UIDP/00532/2020 (CEFT), funded by national funds through FCT/MCTES (PIDDAC). L.L. Ferrás would also like to thank FCT for financial support through CMAT (Centre of Mathematics of the University of Minho) projects UIDB/00013/2020 and UIDP/00013/2020. This work was also financially supported by national funds through the FCT/MCTES (PIDDAC), under the project 2022.06672.PTDC - iMAD - Improving the Modelling of Anomalous Diffusion and Viscoelasticity: solutions to industrial problems. M.L. Morgado acknowledges funding by FCT through projects UIDB/04621/2020 (10.54499/UIDB/04621/2020 https://doi.org/10.54499/UIDB/04621/2020) and UIDP/04621/2020 of CEMAT/ IST-ID, Center for Computational and Stochastic Mathematics, Instituto Superior Técnico, University of Lisbon. This work is also funded by national funds through the FCT - Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UIDB/00297/2020 (https://doi.org/10.54499/UIDB/00297/2020) and UIDP/00297/2020 (https://doi.org/ 10.54499/UIDP/00297/2020) (Center for Mathematics and Applications). Publisher Copyright: © The Author(s) 2024.Electrokinetic flows driven by electro-osmotic forces are especially relevant in micro and nano-devices, presenting specific applications in medicine, biochemistry, and miniaturized industrial processes. In this work, we integrate analytical solutions with numerical methodologies to explore the fluid dynamics of viscoelastic electro-osmotic/pressure-driven fluid flows (described by the generalized Phan–Thien–Tanner (gPTT) constitutive equation) in a microchannel under asymmetric zeta potential conditions. The constitutive equation incorporates the Mittag–Leffler function with two parameters (α and β), which regulate the rate of destruction of junctions in a network model. We analyze the impact of the various model parameters on the velocity profile and observe that our newly proposed model provides a more comprehensive depiction of flow behavior compared to traditional models, rendering it suitable for modeling complex viscoelastic flows.181005437engAnalytical solutionsElectro-osmotic flow under asymmetric zeta potentialGPTT modelMittag-Leffler functionGeneral MathematicsGeneral Engineeringjournal article10.1007/s10665-024-10387-7https://www.scopus.com/pages/publications/85201383470