Almeida E Sousa, MatildeCarvalho, AnaMega, RaquelBilhim, Tiago2023-01-112023-01-112022-101646-0758PURE: 41768595PURE UUID: 03bb9f48-75ed-47e5-b8b2-6822973fe8cbPubMed: 35129430Scopus: 85141254401WOS: 000931694600008http://hdl.handle.net/10362/147353Inflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed tomography showed a 17 mm hypervascular lesion in the confluence of the right and left hepatic ducts, with bile duct ectasia and right liver lobe atrophy. The patient was initially managed as having a Klatskin tumour and underwent right hepatectomy. Histology showed a spindle cell proliferation with an inflammatory infiltrate of lymphocytes, plasma cells and collagen-rich stroma, consistent with an inflammatory myofibroblastic tumour. He was discharged 30 days after admission, and nine months later remains asymptomatic. His liver function tests have normalized and follow-up tests are unremarkable.383736engBile Duct NeoplasmsHepatectomyHepatic DuctCommonKlatskin TumourLiver Function Testsjournal article10.20344/amp.11641https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16976