Basso, MAMarques, CSantos , MDuarte, APissarra, HCarreira, LMGomes, LValério-Bolas, ATavares, LSantos-Gomes, GFonseca Pereira , I2018-05-112018-05-112016PURE: 2463326PURE UUID: 6bf37a2a-054e-45f7-ae67-d621cdc4a2daPubMedCentral: 5362848ORCID: /0000-0001-9264-3887/work/125066180http://hdl.handle.net/10362/36677This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological and biochemical parameters, detection of feline leukaemia virus (FeLV), feline immunodeficiency virus (FIV), feline coronavirus (FCoV) and Leishmania amastigotes. Fine-needle aspiration puncture from the skin nodules was also performed. After definitive diagnosis the animal was treated and followed up over a 2 year period. The animal tested negative for FIV-specific antibodies, FeLV antigen and feline coronavirus RNA. Leishmania amastigotes in the skin nodules were confirmed by cytology and molecular diagnosis. Treatment was initiated with allopurinol, resulting in a slight clinical improvement. Thus, N-methyl-glucamine antimoniate was added and administered for 30 days, with complete closure of the ulcerative lesions in the hindlimbs requiring a surgical approach. Close monitoring of the patient in the following 24 months indicated that combined therapy was safe and clinical cure was achieved without further relapses or side effects.7515202engjournal article10.1177/2055116916630002