Fiscone, CristianaPanzera, IvanManners, David NeilBartiromo, FiorinaVornetti, GianfrancoPollarini, VirginiaRundo, LeonardoLodi, RaffaeleZaccagna, FulvioCastelli, MauroLugaresi, AlessandraTonon, Caterina2024-12-182024-12-182024-05-09PURE: 104178509PURE UUID: ca203f55-e162-4456-a96f-98050572eee8ORCID: /0000-0002-8793-1451/work/173063430http://hdl.handle.net/10362/176519Fiscone, C., Panzera, I., Manners, D. N., Bartiromo, F., Vornetti, G., Pollarini, V., Rundo, L., Lodi, R., Zaccagna, F., Castelli, M., Lugaresi, A., & Tonon, C. (2024). Normal appearing white matter and tracts in patients with multiple sclerosis: susceptibility properties and clinical disability evaluation [abstract]. Abstract from 2024 ISMRM & ISMRT Annual Meeting & Exhibition, Singapore. https://archive.ismrm.org/2024/2981.htmlMotivation: Magnetic susceptibility is influenced by myelin concentration, playing a significant role in the pathogenesis of MS as a demyelinating disease. Goal(s): This study aims to investigate normal-appearing-white-matter in MS patients using QSM, focusing on the cortico-spinal tract and optic radiation, to find non-invasive biomarkers of pre-clinical inflammatory activity. Approach: The automated implemented pipeline relies on the acquisition of multiple MR sequences. Several susceptibility histogram properties were considered and correlated with disability scores. Results: A decrease in myelin concentration was detected in MS group, consistently with the pathophysiology. Correlations between susceptibility and clinical disability occur, distinguishing clinical phenotypes and levels of motor impairment. Impact: Studying the normal-appearing-white-matter tracts using QSM reveals decrease in myelin concentration within cortico-spinal tract and optic radiation in MS patients. Variations were observed between different clinical phenotypes and various levels of motor impairment, suggesting biomarkers for early diagnosis and prognosis.499365engMultiple SclerosisSDG 3 - Good Health and Well-beingNormal appearing white matter and tracts in patients with multiple sclerosisconference objectsusceptibility properties and clinical disability evaluation [abstract]https://archive.ismrm.org/2024/2981.html