Mendes, SaraLeal, Diogo V.Baker, Luke A.Ferreira, AníbalSmith, Alice C.Viana, João L.2023-04-262023-04-262023-041661-6596PURE: 59389374PURE UUID: 1f83e67f-0097-488b-9cb5-7b5b463ab58fScopus: 85152304769PubMed: 37046990WOS: 000970345900001http://hdl.handle.net/10362/152169Funding Information: SM is supported by a Portuguese Foundation of Science and Technology (FCT) doctoral grant (SFRH/BD/07740/2020). The Research Center in Sports Sciences, Health Sciences and Human Development is funded by FCT (UID/04045/2020). Publisher Copyright: © 2023 by the authors.Chronic Kidney Disease (CKD) is a global health burden with high mortality and health costs. CKD patients exhibit lower cardiorespiratory and muscular fitness, strongly associated with morbidity/mortality, which is exacerbated when they reach the need for renal replacement therapies (RRT). Muscle wasting in CKD has been associated with an inflammatory/oxidative status affecting the resident cells’ microenvironment, decreasing repair capacity and leading to atrophy. Exercise may help counteracting such effects; however, the molecular mechanisms remain uncertain. Thus, trying to pinpoint and understand these mechanisms is of particular interest. This review will start with a general background about myogenesis, followed by an overview of the impact of redox imbalance as a mechanism of muscle wasting in CKD, with focus on the modulatory effect of exercise on the skeletal muscle microenvironment.2115740engchronic kidney diseaseexerciseoxidative stressreactive oxygen species (ROS)skeletal muscle wastingCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic Chemistryreview10.3390/ijms24076017https://www.scopus.com/pages/publications/85152304769