Please use this identifier to cite or link to this item:
http://hdl.handle.net/10362/69062| Title: | First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal |
| Author: | Caneiras, Cátia Calisto, Filipa da Silva, Gabriela Jorge Lito, Luis Melo-Cristino, José Duarte, Aida |
| Keywords: | A. Baumannii Antimicrobial resistance Colistin Gram-negative bacteria K. Pneumoniae KPC-3 carbapenemase Tigecycline Microbiology Biochemistry Pharmacology, Toxicology and Pharmaceutics(all) Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| Issue Date: | 1-Dec-2018 |
| Abstract: | Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. |
| Peer review: | yes |
| URI: | http://www.scopus.com/inward/record.url?scp=85057153523&partnerID=8YFLogxK |
| DOI: | https://doi.org/10.3390/antibiotics7040096 |
| ISSN: | 2079-6382 |
| Appears in Collections: | Home collection (ITQB) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| First_Description_of_Colistin_and_Tigecycline_Resistant_Acinetobacter_baumannii_Producing_KPC_3_Carbapenemase_in_Portugal.pdf | 285,85 kB | Adobe PDF | View/Open |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
