Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/43577
Título: Novel in vitro human 3D neural model derived from induced pluripotent stem cells
Autor: Arez, Francisca Maria de Andrade Terras
Palavras-chave: hiPSC
neural differentiation
human neural stem cells
stirred-tank
Data de Defesa: 26-Nov-2015
Editora: Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa
Resumo: The limited access to human neurons has hindered the development of accurate models to mimic human central nervous system (CNS) disease, and consequently the development of efficient therapies for neuropathologies. The current models rely on animal models or on two-dimensional in vitro models that often fail in mimicking human in vivo phenotype. The emergence of human induced pluripotent cells (hiPSC) technology provided an unlimited source of neural precursor cells (NPC) with the ability to differentiate into the neural lineage, including neurons and glia. The possibility to develop in vitro three-dimensional (3D) models that include complexity of microenvironment conditions and interactions, such as cell-cell and cell-extracellular matrix (ECM) interactions, make CNS modeling closer to the in vivo microenvironment.
URI: http://hdl.handle.net/10362/43577
Aparece nas colecções:ITQB: ACM-MA Dissertations

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Francisca Arez_Master Dissertation.pdf3,17 MBAdobe PDFVer/Abrir
Francisca Arez_Abstracts of Master Thesis in Biochemistry for Health_CD.pdf83,24 kBAdobe PDFVer/Abrir


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