Please use this identifier to cite or link to this item: http://hdl.handle.net/10362/23238
Title: Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis
Author: Mourão, Ana Filipa
Santos, Maria José
Mendonça, Sílvia
Oliveira-Ramos, Filipa
Salgado, Manuel
Estanqueiro, Paula
Melo-Gomes, José
Martins, Fernando
Lopes, Ana
Bettencourt, Bruno Filipe
Bruges-Armas, Jácome
Costa, José
Furtado, Carolina
Figueira, Ricardo
Brito, Iva
Branco, Jaime
Fonseca, João Eurico
Canhão, Helena
Keywords: OUTCOME FOLLOWING ONSET
RHEUMATOID-ARTHRITIS
SUSCEPTIBILITY LOCI
INFLAMMATORY ARTHRITIS
DISEASE-ACTIVITY
ASSOCIATION
DISABILITY
DAMAGE
Immunology and Allergy
Immunology
Issue Date: Oct-2015
Abstract: Introduction. This study aimed to assess the genetic determinants of poor outcome in Portuguese patients with juvenile idiopathic arthritis (JIA). Methods. Our study was conducted in Reuma.pt, the Rheumatic Diseases Portuguese Register, which includes patients with JIA. We collected prospectively patient and disease characteristics and a blood sample for DNA analysis. Poor prognosis was defined as CHAQ/HAQ >0.75 at the last visit and/or the treatment with biological therapy. A selected panel of single nucleotide polymorphisms (SNPs) associated with susceptibility was studied to verify if there was association with poor prognosis. Results. Of the 812 patients with JIA registered in Reuma.pt, 267 had a blood sample and registered information used to define "poor prognosis." In univariate analysis, we found significant associations with poor prognosis for allele A of TNFA1P3/20 rs6920220, allele G of TRAF1/C5 rs3761847, and allele G of PTPN2 rs7234029. In multivariate models, the associations with TRAF1/C5 (1.96 [1.17-3.3]) remained significant at the 5% level, while TNFA1P3/20 and PTPN2 were no longer significant. Nevertheless, none of associations found was significant after the Bonferroni correction was applied. Conclusion. Our study does not confirm the association between a panel of selected SNP and poor prognosis in Portuguese patients with JIA.
Peer review: yes
URI: http://www.scopus.com/inward/record.url?scp=84945389456&partnerID=8YFLogxK
http://hdl.handle.net/10362/23238
DOI: http://dx.doi.org/10.1155/2015/706515
ISSN: 2314-8861
Appears in Collections:NMS-FCM: CEDOC - Artigos em revista internacional com arbitragem científica

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