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http://hdl.handle.net/10362/163845| Título: | Dynamic behaviour restructuring mediates dopamine-dependent credit assignment |
| Autor: | Tang, Jonathan C.Y. Paixao, Vitor Carvalho, Filipe Silva, Artur Klaus, Andreas da Silva, Joaquim Alves Costa, Rui M. |
| Palavras-chave: | General |
| Data: | 15-Fev-2024 |
| Resumo: | Initial dopamine self-stimulations reinforced not only the stimulation-producing target action, but also actions similar to the target action and actions that occurred a few seconds before stimulation, and repeated pairings led to a gradual refinement of the behavioural repertoire to home in on the target actions. |
| Descrição: | Funding Information: We thank V. Athalye for feedback; A. Vaz and C. Carvalho for mouse colony management; the members of the Costa laboratory for comments; the members of the Scientific Hardware Platform, Histopathology Platform, Scientific Software Platform and Advanced Bioimaging & BioOptics Experimental Platform (member of the Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122) of the Champalimaud Institute for help; S. Mutlu, D. Bento, P. Carriço., P. Silva and J. Araujo for hardware/software assistance; I. Marcelo for assistance with multinomial logistic regression; N. Loureiro for assistance with inertial sensor calculations; M. Mendoça, C. Alcacer, H. Rodrigues and D. Peterka for help with experimental set-ups; the members of the M. Carey laboratory for sharing apparatus; S. Fusi for project feedback; and R. Junker for advice on dynamic range boxes. This work was supported by Life Sciences Research Fellowship and NINDS K99/R00 Award (1K99NS112575) granted to J.C.Y.T. and National Institute of Health funding (5U19NS104649) and the Aligning Science Across Parkinson’s (ASAP-020551) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF) to R.M.C. The authors have applied a CC BY NC public copyright license for the manuscript. Publisher Copyright: © The Author(s) 2023. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/163845 |
| DOI: | https://doi.org/10.1038/s41586-023-06941-5 |
| ISSN: | 0028-0836 |
| Aparece nas colecções: | NMS - Artigos em revista internacional com arbitragem científica |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| s41586-023-06941-5.pdf | 15,96 MB | Adobe PDF | Ver/Abrir |
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