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Title: Behavioral and synaptic circuit analysis in models of neuropsychiatric disorders: Dissecting the in vivo role of the postsynaptic density proteins nArgBP2 and Shank3 using genetic engineered mice
Authors: Feliciano, Cátia
Orientador: Feng, Guoping
Issue Date: Sep-2011
Publisher: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Abstract: Understanding how discrete genes affect neuronal biology, synaptic function and, ultimately, behavior is a major goal in neuroscience. Not surprisingly, genes believed to be involved in human psychiatric and developmental brain disorders garner the most attention due to the likelihood that their disruption will promote salient changes in neurobiological functions. They also promise to nurture further understanding of relevant biomedical questions. Using the mouse as a model organism accelerates this discovery process because the species is amenable to manipulation at the genetic level, allowing for the orthologous recreation of human mutations. Simultaneously, our understanding of murine behavioral outputs can now be linked to particular endophenotypes reminiscent of human disorders.(...)
Description: Dissertation presented to obtain the Ph.D degree in Biology
Appears in Collections:ITQB: LA - PhD Theses

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