DSpace UNL

Instituto de Tecnologia Química e Biológica (ITQB) >
ITQB R&D Units >
ITQB: LA - PhD Theses >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10362/6179

Título: Mitosis and protein Na-terminal acetylation
Autor: Pimenta-Marques, Ana
Orientador: Martinho, Rui
Issue Date: Jul-2011
Editora: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Resumo: Protein N-terminal acetylation is a highly conserved and widespread modification that occurs on approximately 80% of all soluble, cytoplasmic human proteins. Nevertheless, with few exceptions, little is known about the biological function of protein N- acetylation. Recently, it was suggested to act as a general protein destabilization signal in yeast (Hwang et al., 2010). Yet, other reports suggest it might act as stabilizer, for instance by blocking protein degradation (Ciechanover and Ben-Saadon, 2004). This protein modification is catalyzed by N-terminal acetyltransferases (NATs), which are highly conserved from yeast to humans both in subunit composition and substrate specificity (Starheim et al., 2009). Since NATs enzymatic activity and function has been mostly studied in yeast and tissue culture cells, our current understanding of the role of these enzymes during development of multicellular organisms is extremely poor, being our main goal to understand the role of this ubiquitous protein modification during development.(...)
Descrição: Dissertation presented to obtain the Ph.D degree in Developmental Biology
URI: http://hdl.handle.net/10362/6179
Appears in Collections:ITQB: LA - PhD Theses

Files in This Item:

File Description SizeFormat
PhD_Ana Marques.pdf20,4 MBAdobe PDFView/Open

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Universidade Nova de Lisboa  - Feedback
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia