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Please use this identifier to cite or link to this item: http://hdl.handle.net/10362/5793

Título: Molecular modelling of ABC transporters: from ATP hydrolysis to substrate transport
Autor: Oliveira, Ana Sofia Fernandes
Orientador: Soares, Cláudio M.
Issue Date: Aug-2010
Editora: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Resumo: Despite the great advances that have been made in the past decades in the ABC transporters field, the molecular mechanisms involved in transport across membranes remains largely an enigma. To date, questions regarding the molecular mechanism of transport, nucleotide hydrolysis and inorganic phosphate exit from the binding sites are still unanswered. In this thesis the dynamic behavior of several ABC transporters during the ATP-hydrolytic cycle is investigated using molecular modeling methods. The content of this thesis is compiled in three main scientific publications [1-3], corresponding to sections 3, 4 and 5, respectively. Although these three works are performed in prokaryotic family ABC transporters, it is likely that eukaryotic ones use similar mechanisms for nucleotide hydrolysis, inter-domain communication and allocrite translocation.(...)
Descrição: Dissertação para a obtenção de grau de doutor em Bioquímica pelo Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa
URI: http://hdl.handle.net/10362/5793
Appears in Collections:ITQB: PM - PhD Theses

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