http://hdl.handle.net/10362/3728 Wed, 22 May 2013 23:45:35 GMT 2013-05-22T23:45:35Z http://hdl.handle.net/10362/5790 Title: Metabolic and morphogenetic engineering of Bacillus subtilis: biotechnology for industry Authors: Potot, Sébastien Abstract: The bacterium Bacillus subtilis plays a major role as model for Gram-positive research, and is widely used as industrial workhorse for the production of high-value enzymes and metabolites. Successful development of commercially-attractive strains and of original products is the key of innovation in microbial industry. Evolving a natural B. subtilis strain into an overproducer involves genetic engineering. In spite of a wide range of genetic tools and techniques available for B. subtilis, engineering of the metabolic pathways, with the purpose to reach industrially significant amount of products, requires a deep and specific understanding of the metabolism.(...) Description: Dissertation presented to obtain the Ph.D. degree in “Biology” at the Institute of Chemical and Biological Technology of the New University of Lisbon Mon, 01 Nov 2010 00:00:00 GMT http://hdl.handle.net/10362/5790 2010-11-01T00:00:00Z