http://hdl.handle.net/10362/3442 2013-05-22T05:28:22Z http://hdl.handle.net/10362/8559 Title: Yeast as a model system to study genetic and post-translational regulation of metabolic pathways in mammals Authors: Batista-Nascimento, Liliana Abstract: The work presented in this thesis describes the use of yeast Saccharomyces cerevisiae as a model system to study two different stress response processes and its extrapolation to higher eukaryotes.(...) Description: Dissertation presented to obtain the Ph.D degree in Biology 2012-06-01T00:00:00Z http://hdl.handle.net/10362/4075 Title: Deciphering the role of Yap4 phosphorylation under stress conditions Authors: Pereira, Jorge Abstract: The existence of molecular mechanisms of response, repair and adaptation, many of which are greatly conserved across nature, gives to the cell with the plasticity it requires to adjust to its ever-changing environment, a homeostatic event that is termed the stress response. In the budding yeast Saccharomyces cerevisiae there is a particular family of transcription factors, the Yap family, which has been shown to have a relevant role in yeast adaptation to several stress conditions. In particular, Yap1 is the major regulator of the transcriptional response to oxidative stress and Yap2 and Yap8 play important roles upon cadmium and arsenic exposure, respectively.(...) 2008-12-01T00:00:00Z